Despite an overhaul in the system for donor lung allocation to reduce death rates on the waiting list, nearly 1 in 5 patients listed for lung transplantation dies before receiving a suitable donor offer. After transplant, there are trends towards increasing complications in the perioperative period; the immediate post-transplant hospital stay lasts more than a month for one in four patients and half are discharged to places other than home without in-home nursing support (e.g. skilled nursing facility).
The focus of this study is to perform an early phase home-based interventional trial to treat frailty in lung transplant candidates. The hypothesis is that a multimodal aerobic and strength training exercise program delivered through the Aidcube platform coupled with nutrition optimization will be feasible and improve Short Physical Performance Battery frailty scores, daily activity (by wearable monitor), and patient reported disability and health related quality of life.
UCSF chose to use the Aidcube platform, a fully customizable, commercially available digital “app”-based platform to deliver home-based pulmonary rehabilitation for patients with COPD based on ERS/ATS guidelines.
In partnership with UCSF, we customized the suite of exercises and features of our platform to meet the specific needs of the pilot study to treat frailty in lung transplant candidates in the United States.
On the patient-facing side, participants can view their daily exercise prescription, descriptions and videos demonstrating correct execution of the exercises, document completion of exercises, and message their health-care provider. On the provider-facing side, UCSF investigators can choose from over 150 available exercises, surveys, and activities to design a personalized and fully-customized exercise prescription. Based on real-time participant feedback, the exercise prescription can be progressed (i.e., advanced and/or modified) by adding repetitions or time to specific exercises or adding new activities. UCSF investigators can also message the patient from within the Aidcube environment. Weekly emails are automatically sent to the UCSF investigators summarizing each participants activity over the prior 7 days.
Results will become available on this page, when the study is has been completed (during 2017).